Controlling cell migration

Latest research

1. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

   Jessica Gray, Von Vergel L Torres ... Ian R Henderson
2. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

   Gregory Caleb Howard, Jing Wang ... William P Tansey

   Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
3. 1. Neuroscience

   A new ‘CFS tracking’ paradigm reveals uniform suppression depth regardless of target complexity or salience

   David Alais, Jacob Coorey ... Matthew J Davidson

   A new and efficient continuous flash suppression (CFS) method is presented that provides breakthrough and suppression thresholds to quantify depth of target suppression.
4. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

   Taegon Chung, Iksoo Chang, Sangyeol Kim

   ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.
5. 1. Cancer Biology
   2. Cell Biology

   N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion

   Julian JA Hoving, Elizabeth Harford-Wright ... Alison C Lloyd

   N-cadherin and Slit2/3/Robo interactions provide the outward force to drive collective Schwann cell migration during nerve regeneration, identifying a dual role for N-cadherin in both adhesion and repulsion processes during Schwann cell collective migration.
6. 1. Microbiology and Infectious Disease

   Birnaviral Hijacking of Endosomal Membranes

   Flavia A. Zanetti, Ignacio Fernández ... Laura R. Delgui
7. 1. Plant Biology

   Pectin methylesterase activity is required for RALF1 peptide signalling output

   Ann-Kathrin Rößling, Kai Dünser ... Jürgen Kleine-Vehn
8. 1. Immunology and Inflammation

   Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4⁺ T cells through STAT1-related epigenetic mechanisms

   Jie Zhang, Hui Tang ... Yu Zhang
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A modular platform to display multiple hemagglutinin subtypes on a single immunogen

   Dana Thornlow Lamson, Faez Amokrane Nait Mohamed ... Aaron G. Schmidt
10. 1. Neuroscience

    High Frequency Terahertz Stimulation Alleviates Neuropathic Pain by Inhibiting the Pyramidal Neuron Activity in the Anterior Cingulate Cortex of mice

    Wenyu Peng, Pan Wang ... Tao Chen