Highlights

  • Complex connections

    Optogenetics reveals that interactions between the basal ganglia and the pedunculopontine nucleus (PPN), a region that has a central role in motor control, are more complex than previously thought.

    Michel Fallah, Kenea C Udobi ... Rebekah C Evans
    Research Article
  • The benefits of disorder

    The presence of an intrinsically disordered region in a transcription factor enhances both target binding and search efficiency.

    Wencheng Ji, Ori Hachmo ... Ariel Amir
    Reviewed Preprint Updated
  • Genetic parallels

    Multiple genetic analyses reveal surprising parallels between biomineralization in stony corals and certain sponges.

    Oliver Voigt, Magdalena V Wilde ... Gert Wörheide
    Research Article

Latest research

    1. Neuroscience

    In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging

    Vasileios Ioakeimidis, Marco Palombo ... Claudia Metzler-Baddeley
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    DIRseq: a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

    Matthew MacAinsh, Sanbo Qin, Huan-Xiang Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

    Wei-Ping Li, Jia-Ying Su ... Chien-Ling Lin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dissociation of the nuclear basket triggers chromosome loss in aging yeast

    Mihailo Mirkovic, Jordan McCarthy ... Yves Barral
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Immunology and Inflammation

    Protein phase change batteries drive innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage assisted behavioral innovation and testing system

    Bowen Yu, Penghai Li ... Yaoyao Hao
    Fully autonomous home-cage training system HABITS enables mice to learn complex cognitive behaviors without human intervention, expanding behavioral paradigms and optimizing training efficiency through machine teaching algorithms.
    1. Microbiology and Infectious Disease

    Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation with implications for gut colonization dynamics in Ciona robusta

    Ojas Natarajan, Susanne L Gibboney ... Larry J Dishaw
    Deleting SfPat prophage reduces Shewanella fidelis motility, increases biofilms, changes pdeB expression and spatial retention in Ciona gut, while Ciona VCBP-C binding to the WT strain results in reduced expression of viral capsid proteins without inducing SOS, indicating tripartite interactions.
    1. Neuroscience

    Structure transfer and consolidation in visual implicit learning

    Dominik Garber, József Fiser
    Sleep is essential for consolidating implicitly acquired perceptual knowledge that enables the knowledge transfer effect via newly learned structured information observed in prior studies of explicit learning.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Magnetotactic bacteria optimally navigate natural pore networks

    Alexander P Petroff, Julia Hernandez ... Nina Radchenko-Hannafin
    Diverse magnetotactic bacteria are adapted to the local geomagnetic field and grain size to maximize their swimming speed through the pore space.
    1. Cancer Biology
    2. Computational and Systems Biology

    Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

    Erika Tsingos, Advaita M Dick, Baubak Bajoghli
    Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.